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Cardiolite (Atenolol)

Information for medical Professionals

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Each Cardiolite 25 mg tablet contains 25 mg of atenolol.
Each Cardiolite 50 mg tablet contains 50 mg of atenolol.
Each Cardiolite 100 mg tablet contains 100 mg of atenolol.

MECHANISM OF ACTION
Atenolol is a beta-adrenoceptor blocking agent. It is a cardioselective beta-blocker selective for cardiac beta1 receptors and has no partial agonist or membrane stabilising activity.
The mode of action of atenolol in the moderation of hypertension is still not fully understood although its effects on plasma renin and cardiac output are probably of primary importance. Atenolol reduces cardiac output, alters baroreceptor reflex sensitivity and blocks peripheral adrenoceptors. Atenolol has been found to reduce systolic and diastolic blood pressures by about 15% in patients with mild to moderate hypertension. Its beta-adrenoceptor antagonist properties reduce cardiac work. This property improves exercise tolerance in anginal patients.

PHARMACOKINETICS

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Atenolol is not completely absorbed from the gastrointestinal tract, its oral bioavailability being of the order 50-60%.

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It is approximately 5% bound to plasma proteins. The plasma half-life of atenolol is about 6 hours. However, the duration of therapeutic effect is much longer than this, allowing once daily dosing.

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Atenolol is excreted largely unchanged in the urine and its dosage should be adjusted in renal failure.

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Cardiolite may be used alone or concomitantly with other antihypertensive agents, particularly with a thiazide-type diuretic.
Angina Pectoris Due to Coronary Atherosclerosis
Cardiolite is indicated for the long-term management of patients with angina pectoris.
Acute Myocardial Infarction
Cardiolite is indicated in the management of hemodynamically stable patients with definite or suspected acute myocardial infarction to reduce cardiovascular mortality. Treatment can be initiated as soon as the patient's clinical condition allows.

 

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